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Большинству женщин достаточно приема прогестерона в течение первого триместра беременности (в первые 12 недель), но иногда, при постоянном гипертонусе матки (повышенной сократительной активности мускулатуры матки) дюфастон назначают до конца второго триместра (до 24 недели).

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При недостаточном гормональном обеспечении (неполноценной лютеиновой фазе) второй половины менструального цикла слизистая оболочка полости матки не может выделять достаточно секрета, что препятствует прикреплению оплодотворенной яйцеклетки к слизистой оболочке полости матки. Это связано со снижением функции желтого тела яичников. Но бывает, что гормональный фон нормальный, а проблема в том, что рецепторы, расположенные в матке плохо воспринимают прогестерон. Часто такие изменения в матке происходят на фоне хронических воспалительных процессов.

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Иногда прерывание беременности в самом ее начале происходит из-за формирования неполноценного плодного яйца, ворсины которого не вырабатывают достаточного количества хорионического гонадотропина – гормона беременности, задачей которого является стимуляция секреции прогестерона желтым телом.
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